Leukotriene C4 synthase promoter polymorphism in aspirin - induced asthma / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
; : 542-547, 1999.
Article
in Ko
| WPRIM
| ID: wpr-193530
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Aspirin/NSAIDs can release cysteinyl-leukotriene (cys-LTs) into airways and precipitate asthmatic symptoms in aspirin - induced asthma(AIA). It has been reported that there is profound overexpression of LTC4 synthase in their bronchial mucosa, compared to aspirin-tolerant asthma. Objective : We observed whether genetic polymorphism of LTC4 synthase may be predisposed to LTC4 synthase overexpression in AIA. Subject and METHOD: Forty - four AIA patients having positive responses on lysin aspirin bron choprovocation tests and 47 non - aspirin induced asthma ( non - AIA ) patients having negative challenges and 32 healthy controls were enrolled. The genotypes of the promoter LTC4 synthase gene ( A,C transversion ) were determined by polymerase chain reaction and restriction fragment length polymorphism ( RFLP ) method. RESULTS: LTC4 synthase promoter polymorphism ( A444C btransversion) was not significantly different between non - AIA and AIA patients (p>0.05). Conclusion These findings suggest that genetic polymorphism of LTC4 synthase promoter may not be predisposed to LTC, synthase overexpression in AIA.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Polymorphism, Genetic
/
Asthma
/
Polymorphism, Restriction Fragment Length
/
Aspirin
/
Polymerase Chain Reaction
/
Leukotriene C4
/
Asthma, Aspirin-Induced
/
Genotype
/
Mucous Membrane
Limits:
Humans
Language:
Ko
Journal:
Journal of Asthma, Allergy and Clinical Immunology
Year:
1999
Document type:
Article