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Predictive Value of Dental Maturity for a Positive Gonadotropin-Releasing Hormone Stimulation Test Result in Girls with Precocious Puberty
Article in English | WPRIM (Western Pacific) | ID: wpr-193558
Responsible library: WPRO
ABSTRACT
Dental maturity is associated with skeletal maturity, which is advanced in girls with central precocious puberty (CPP). We investigated the performance of dental maturity as a screening method for CPP using mandibular second premolar and molar calcification stages, assessed the associated anthropometric and laboratory factors, and evaluated pubertal response predictors using the gonadotropin-releasing hormone stimulation test (GnRHST) in prepubertal and pubertal girls. A prospective case-control study was conducted in girls, aged 7.0–8.9 years, classified into pubertal (peak luteinizing hormone [LH] after GnRHST ≥ 5 IU/L), prepubertal (peak LH < 5 IU/L), and control groups. Auxological and biochemical tests, panoramic radiographs, and GnRHSTs in participants with breast development were conducted. Dental maturity was assessed using the Demirjian index (DI). We included 103 girls (pubertal, 40; prepubertal, 19; control, 44). Chronological age (CA) was not significantly different between groups. Bone age (BA) and BA advancement was higher in the pubertal and prepubertal groups. Increased DI values at the mandibular second premolar and molar were significantly associated with CA, BA, BA advancement, height standard deviation score (SDS), peak LH after GnRHST, and insulin-like growth factor-I (IGF-I) (all P < 0.05). Moreover, odds ratio (OR) of the mandibular second premolar and molar (a DI value of ≥ E) for predicting a positive response to GnRHST was 8.7 (95% confidence intervals [CI], 2.9–26.1) and 5.2 (95% CI, 2.2–12.7), respectively. Dental maturity was a strong predictor for diagnosing CPP. Determining dental maturity in girls with suspected precocious puberty might help determine the performance of GnRHSTs.
Subject(s)

Full text: Available Health context: SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases Health problem: Endocrine System Diseases / Oral Conditions and Disorders Database: WPRIM (Western Pacific) Main subject: Puberty, Precocious / Bicuspid / Breast / Luteinizing Hormone / Case-Control Studies / Odds Ratio / Mass Screening / Prospective Studies / Gonadotropin-Releasing Hormone / Diagnosis Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors / Screening study Limits: Female / Humans Language: English Journal: Journal of Korean Medical Science Year: 2017 Document type: Article
Full text: Available Health context: SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases Health problem: Endocrine System Diseases / Oral Conditions and Disorders Database: WPRIM (Western Pacific) Main subject: Puberty, Precocious / Bicuspid / Breast / Luteinizing Hormone / Case-Control Studies / Odds Ratio / Mass Screening / Prospective Studies / Gonadotropin-Releasing Hormone / Diagnosis Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors / Screening study Limits: Female / Humans Language: English Journal: Journal of Korean Medical Science Year: 2017 Document type: Article
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