Efficacy of Levofloxacin-Based Third-Line Therapy for the Eradication of Helicobacter pylori in Peptic Ulcer Disease
Gut and Liver
; : 226-231, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-194966
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
The resistance rate of Helicobacter pylori is gradually increasing. We aimed to evaluate the efficacy of levofloxacin-based third-line H. pylori eradication in peptic ulcer disease.METHODS:
Between 2002 and 2014, 110 patients in 14 medical centers received levofloxacin-based third-line H. pylori eradication therapy for peptic ulcer disease. Of these, 88 were included in the study; 21 were excluded because of lack of follow-up and one was excluded for poor compliance. Their eradication rates, treatment regimens and durations, and types of peptic ulcers were analyzed.RESULTS:
The overall eradiation rate was 71.6%. The adherence rate was 80.0%. All except one received a proton-pump inhibitor, amoxicillin, and levofloxacin. One received a proton-pump inhibitor, amoxicillin, levofloxacin, and clarithromycin, and the eradication was successful. Thirty-one were administered the therapy for 7 days, 25 for 10 days, and 32 for 14 days. No significant differences were observed in the eradication rates between the three groups (7-days, 80.6% vs 10-days, 64.0% vs 14-days, 68.8%, p=0.353). Additionally, no differences were found in the eradiation rates according to the type of peptic ulcer (gastric ulcer, 73.2% vs duodenal/gastroduodenal ulcer, 68.8%, p=0.655).CONCLUSIONS:
Levofloxacin-based third-line H. pylori eradication showed efficacy similar to that of previously reported first/second-line therapies.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 10: Communicable diseases
Database:
WPRIM (Western Pacific)
Main subject:
Peptic Ulcer
/
Ulcer
/
Follow-Up Studies
/
Helicobacter pylori
/
Helicobacter
/
Clarithromycin
/
Compliance
/
Levofloxacin
/
Amoxicillin
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2017
Document type:
Article