Myeloablative Hematopoietic Stem Cell Transplantation with a Non-total Body Irradiation Regimen for Treating Pediatric Acute Lymphoblastic Leukemia / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
; : 55-63, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-197955
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Total body irradiation (TBI) has been traditionally used as a conditioning regimen prior to hematopoietic stem cell transplantation (HSCT) in patients with pediatric leukemia. However, TBI can cause late sequelae such as growth impairment, cataract, hormone abnormalities, infertility, neurocognitive effects, and secondary malignancy in pediatric patients.METHODS:
This single center retrospective study included 22 patients with acute lymphoblastic leukemia who were aged <18 years and underwent HSCT between May 1999 and December 2014; seven patients received a TBI-based regimen and 15 received a non-TBI regimen.RESULTS:
The overall survival and event-free survival rates in the TBI group were not significantly different from those in the non-TBI group (overall survival rate 71% vs. 73%, respectively; P=0.906; event-free survival rate 71% vs. 73%, respectively P=0.923).CONCLUSION:
Our results indicate that non-TBI conditioning regimens can be an alternative treatment option of the treatment of pediatric acute lymphoblastic leukemia undergoing HSCT.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Cataract
/
Hematopoietic Stem Cells
/
Leukemia
/
Survival Rate
/
Retrospective Studies
/
Whole-Body Irradiation
/
Hematopoietic Stem Cell Transplantation
/
Disease-Free Survival
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Infertility
Type of study:
Observational study
Limits:
Child
/
Humans
Language:
English
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2017
Document type:
Article