Molecular Pathogenesis of Hepatitis-B-virus-associated Hepatocellular Carcinoma
Gut and Liver
; : 101-117, 2007.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-198228
Responsible library:
WPRO
ABSTRACT
Hepatocellular carcinoma (HCC) is one of the most frequent and malignant diseases worldwide. Epidemiological studies have clearly demonstrated that chronic hepatitis B virus (HBV) infection is a major etiological factor in the development of HCC. The pathogenesis of HBV-associated HCC has been studied extensively, and the molecular changes associated with malignant transformation have been identified. The predominant carcinogenic mechanisms of HBV-associated HCC are chronic inflammation and the effects of cytokines in the development of fibrosis and liver cell proliferation. An important role is also played by the integration of HBV DNA into host cellular DNA, which disrupts or promotes the expression of cellular genes that are important in cell growth and differentiation. Especially, HBx protein is a transactivating protein that promotes cell growth, survival, and the development of HCC. Continued investigation of the mechanisms underlying hepatocarcinogenesis will refine our current understanding of the molecular and cellular basis for neoplastic transformation in the liver. Prevention of HBV infections and effective treatments for chronic hepatitis B are still needed for the global control of HBV-associated HCC. This review summarizes the current knowledge on the mechanisms involved in HBV-associated hepatocarcinogenesis.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.3: End transmission of communicable diseases
Database:
WPRIM (Western Pacific)
Main subject:
Fibrosis
/
DNA
/
Trans-Activators
/
Hepatitis B virus
/
Cytokines
/
Carcinoma, Hepatocellular
/
Hepatitis B, Chronic
/
Cell Proliferation
/
Inflammation
/
Liver
Type of study:
Etiology study
/
Prognostic study
Language:
English
Journal:
Gut and Liver
Year:
2007
Document type:
Article