Osseointegration of the titanium implant coated with rhTGF-beta2/PLGA particles by electrospray: a preliminary microCT analyzing rabbit study / 대한치과보철학회지
The Journal of Korean Academy of Prosthodontics
; : 298-304, 2014.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-201572
Responsible library:
WPRO
ABSTRACT
PURPOSE:
This preliminary rabbit study was conducted to evaluate the effect of recombinant human transforming growth factor-beta2 (rhTGF-beta2)/poly lactic-co-glycolic acid (PLGA) coating on osseointegration of the titanium (Ti) implant. MATERIALS ANDMETHODS:
Eight Ti implants were anodized with 300 voltages for three minutes. Four of those were coated with rhTGF-beta2/PLGA by an electrospray method as the experimental group. The implants were placed into tibiae of four New Zealand rabbits, two implants per a tibia, one implant per each group. After 3 and 6 weeks, every two rabbits were sacrificed and micro-computed tomography (microCT) was taken for histomorphometric analysis.RESULTS:
In scanning electron microscope (SEM) image, the surface of rhTGF-beta2/PLGA coated Ti implant showed well distributed particles. Although statistically insignificant, microCT analysis showed that experimental group has higher bone volume / total volume (BV/TV) and trabecular thickness (Tb.Th) values relatively. Cross sectional view also showed more newly formed bone in the experimental group.CONCLUSION:
In the limitation of this study, rhTGF-beta2/PLGA particles coating on the Ti implant show the possibility of more favorable quantity of newly formed bone after implant installation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Tibia
/
Titanium
/
Osseointegration
/
Transforming Growth Factor beta2
/
X-Ray Microtomography
Limits:
Animals
/
Humans
Language:
Korean
Journal:
The Journal of Korean Academy of Prosthodontics
Year:
2014
Document type:
Article