Detection of Clarithromycin-resistant Strains from Clinical Isolates of Mycobacterium abscessus / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 422-426, 2008.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-201625
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Mycobacterium abscessus is the most pathogenic and drug-resistant rapid-growing mycobacterium. Clarithromycin or azithromycin are the only regular oral antimycobacterial agents that have an effect on M. abscessus. We tried to detect the clarithromycin-resistant strains from the clinical isolates of M. abscessus.METHODS:
We tried to isolate the clarithromycin-resistant strains from 220 clinical isolates of M. abscessus by performing using reverse hybridization assay (RHA) and the broth microdilution test (BMT).RESULTS:
Seven resistant strains (3.2%) from all the tested clinical isolates were detected by BMT. Three of these resistant strains were also detected by RHA and it was confirmed that they had point mutants.CONCLUSION:
These results showed that clarithromycin resistance in M. abscessus clinical isolates is related to a point mutation and other unknown mechanisms.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Chimera
/
Point Mutation
/
Clarithromycin
/
Azithromycin
/
Anti-Bacterial Agents
/
Mycobacterium
Type of study:
Diagnostic study
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2008
Document type:
Article