Neuroprotective Effect of Fucoidan against N-methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampus
Experimental Neurobiology
; : 123-128, 2009.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-202565
Responsible library:
WPRO
ABSTRACT
Fucoidan, a sulfated polyanionic polymer of L-fucose, is obtained from brown marine macroalgae. In the present study, neuroprotective effect of fucoidan against N-methyl- D-aspartate (NMDA)-induced excitotoxicity in the hippocampus was investigated. The patch clamp study revealed that fucoidan significantly inhibited NMDA receptor-activated ion current in the acutely dissociated hippocampal CA1 neurons. In an organotypic hippocampal slice culture, fucoidan inhibited NMDA-induced neuronal cell death in a dose-dependent manner. The present study showed that fucoidan possesses a neuroprotective effect against NMDA-induced excitotoxicity, and that the suppressive effect of fucoidan on the NMDA-induced ion current can be suggested as being the underlying neuroprotective mechanism of fucoidan.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polymers
/
Polysaccharides
/
Seaweed
/
N-Methylaspartate
/
Cell Death
/
Neuroprotective Agents
/
D-Aspartic Acid
/
Hippocampus
/
Neurons
Limits:
Animals
Language:
English
Journal:
Experimental Neurobiology
Year:
2009
Document type:
Article