Risk factors and long-term outcomes of delayed graft function in deceased donor renal transplantation
Annals of Surgical Treatment and Research
; : 208-214, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-204414
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The purpose of this study was to analyze the risk factors for delayed graft function (DGF) and determine its impact on the outcomes of deceased donor (DD) kidney transplantation (KT).METHODS:
Between January 2000 and December 2011, we performed 195 DD renal transplants. After the exclusion of primary nonfunctional grafts (n = 4), the study recipients were divided into two groups-group I, DGF (n = 31, 16.2%); group II, non-DGF (n = 160, 83.8%). The following variables were compared donor and recipient characteristics, patient and graft survival, postoperative renal function, acute rejection (AR) episodes, and the rates of surgical and infectious complications.RESULTS:
Donor-related variables that showed significant differences included hypertension (P = 0.042), diabetes (P = 0.025), and prerecovery serum creatinine levels (P 20%, P = 0.008). On multivariate analysis, only the prerecovery serum creatinine level (P < 0.001; hazard ratio [HR], 1.814) was an independent risk factor for the development of DGF. A Cox multivariate analysis of risk factors for graft survival identified these independent risk factors for graft survival nephron mass (donor kidney weight to recipient body weight ratio) index (P = 0.026; HR, 2.328), CMV infection (P = 0.038; HR, 0.114), and AR episode (P = 0.038; HR, 0.166).CONCLUSION:
In DD KT, an independent risk factor for DGF was the prerecovery serum creatinine level. Although there was a significant difference in graft survival between the DGF and non-DGF groups, DGF was not an independent risk factor for graft failure in this study.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Tissue Donors
/
Body Weight
/
Multivariate Analysis
/
Risk Factors
/
Kidney Transplantation
/
Transplants
/
Creatinine
/
Delayed Graft Function
/
Graft Survival
/
Hypertension
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Annals of Surgical Treatment and Research
Year:
2015
Document type:
Article