Three Cases of Autoimmune Thyroid Disease in a Family through Three Generation / 대한내분비학회지
Journal of Korean Society of Endocrinology
; : 238-244, 2001.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-205578
Responsible library:
WPRO
ABSTRACT
According to recent studies, the immunogenetic factors are thought to be account for a part of the etiopathogenesis of autoimmune thyroid disease. In Korea, there was one report on the relationship between HLA DR5, DR8, B13 and autoimmune thyroid disease. There were also several reports on a familial hereditary transmission of autoimmune thyroid disease in other countries but not in Korea. We describe the occurrence of autoimmune thyroid disease that affected three members of a family through three generations. This is the first report on familial hereditary transmission of autoimmune thyroid disease in Korea. We report on an 80-year-old woman who presented with Hashimoto's thyroiditis, her 53-year-old daughter who had Graves' disease, and her 29-year-old grand-daughter who had Graves' disease. In order to identify the immunogenetic influence in these cases, HLA haplotypes & thyroid autoantibody were studied. HLA DRB3*02 was obseved in each of the patents. HLA DQB1*0301, DR11, DQB1*05031 and DR14 were observed in the two cases. However, HLA B13, DR5 and DR8 were not observed. The patients are currently undergoing follow-up using PTU, methimazole and synthyroid medication.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Thyroid Diseases
/
Thyroid Gland
/
Thyroiditis
/
Haplotypes
/
Nuclear Family
/
Graves Disease
/
Family Characteristics
/
Follow-Up Studies
/
HLA-B13 Antigen
/
Immunogenetics
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Aged, 80 and over
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of Korean Society of Endocrinology
Year:
2001
Document type:
Article