Genome-wide Association Study Identified TIMP2 Genetic Variant with Susceptibility to Osteoarthritis
Genomics & Informatics
; : 121-126, 2011.
Article
in En
| WPRIM
| ID: wpr-205647
Responsible library:
WPRO
ABSTRACT
Osteoarthritis (OA) is the most common degenerative joint disorder in the elderly population. To identify OA-associated genetic variants and candidate genes, we conducted a genome-wide association study (GWAS). A total 3,793 samples (476 cases: wrist + knee and 3317 controls) from a community-based epidemiological study were genotyped using the Affymetrix SNP 5.0. An intronic SNP (rs4789934) in the TIMP2 (tissue inhibitor of metalloproteinase-2) showed the most significance with OA (odd ratio [OR] = 2.06, 95% confidence interval [CI] = 1.52-2.81, p = 4.01 x 10(-6)). Furthermore, a polymorphism (rs1352677) in the NKAIN2 (Na+/K+ transporting ATPase interacting 2) was suggestively associated with OA (OR = 1.43, CI = 1.22-1.66, p = 7.01 x 10(-6)). The present study provides new insights into the identification of genetic predisposing factors for OA.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Osteoarthritis
/
Wrist
/
Introns
/
Epidemiologic Studies
/
Adenosine Triphosphatases
/
Genome-Wide Association Study
/
Joints
/
Knee
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Aged
/
Humans
Language:
En
Journal:
Genomics & Informatics
Year:
2011
Document type:
Article