Concentration of Non-Steroidal Anti-Inflammatory Drugs in the Pelvic Floor Muscles: An Experimental Comparative Rat Model
Yonsei Medical Journal
; : 1095-1100, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-207153
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. MATERIALS ANDMETHODS:
We used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma).RESULTS:
Diclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85+/-0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs.CONCLUSION:
Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Thiazines
/
Thiazoles
/
Butanones
/
Piroxicam
/
Anti-Inflammatory Agents, Non-Steroidal
/
Diclofenac
/
Naproxen
/
Rats, Wistar
/
Pelvic Pain
/
Pelvic Floor
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Yonsei Medical Journal
Year:
2014
Document type:
Article