Clinical Study of Adrenal Incidentaloma in Korea
The Korean Journal of Internal Medicine
; : 303-309, 2005.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-20726
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
This study was designed to evaluate the clinical, endocrinological and histological characteristics of adrenal incidentalomas.METHODS:
Eighty patients (41, males; 38, females; age range 17-80 years) who were diagnosed with adrenal incidentaloma at Korea University Hospital from 1992 to 2003 were studied retrospectively.RESULTS:
Endocrinological investigation revealed 16 pheochromocytomas (20%), nine Cushing's syndromes (11%), eight primary aldosteronism (10%) and 46 non-functioning tumors (58%). Forty-four patients received operations, and biopsies were performed on two patients. Pathologic examination revealed 16 adrenocortical adenomas (20%), five carcinomas (6%), 13 pheochromocytomas (16%), three metastatic cancers (4%), and other tumors (10%). The diameter of the carcinomas (mean 10.8 cm, range 5-19 cm) were significantly larger than the diameter of benign adenomas (mean 2.84 cm, range 1-6 cm) (p=0.002). According to the receiver operating charactenstic (ROC) curve analysis, the cut-off value of tumor size for discriminate malignant tumor was 4.75 cm (sensitivity 90%, specificity 58%). Twenty-four patients with non-functioning tumors were followed up for a period of 3 to 72 months. During the follow up period, two patients showed an increase in tumor size of more than 1 cm, and one patient developed Cushing's syndrome. Changes in mass size and function were observed only between 10 and 26 months after the initial diagnosis.CONCLUSIONS:
These data show that an endocrine evaluation should be performed in all adrenal incidentalomas, and an adrenalectomy is recommended for tumors 5 cm or greater or tumors with adrenocortical hyperfunction. In addition, these tumors should be monitored for changes in mass size and function for a follow up period of approximately 26 months.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pheochromocytoma
/
Carcinoma
/
Retrospective Studies
/
Adrenal Gland Neoplasms
/
Adrenocortical Adenoma
/
Incidental Findings
/
Korea
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Aged, 80 and over
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2005
Document type:
Article