Two Cases of Antituberculosis Drug-induced Hypersensitivity Syndrome / 대한피부과학회지
Korean Journal of Dermatology
; : 635-639, 2007.
Article
in Ko
| WPRIM
| ID: wpr-209424
Responsible library:
WPRO
ABSTRACT
Drug-induced hypersensitivity syndrome is a rare, but severe, life-threatening disease with multiorgan failure. Aromatic antiepileptic drugs are frequent causes of this syndrome. The association of the human herpes virus-6 has been recently reported in patients with drug-induced hypersensitivity syndrome. We report two patients who were diagnosed as having antituberculosis drug-induced hypersensitivity syndrome based on clinical course and laboratory data. In addition, human herpes virus-6 DNA was detected by polymerase chain reaction in peripheral blood mononuclear cells and the serum. There was a favorable outcome after discontinuation of the causative drug, plus corticosteroid therapy. After the treatment, human herpes virus-6 DNA was not detected by polymerase chain reaction. This is the first report of antituberculosis drug-induced hypersensitivity syndrome associated with reactivation of human herpes virus-6.
Key words
Full text:
1
Database:
WPRIM
Main subject:
DNA
/
Polymerase Chain Reaction
/
Hypersensitivity
/
Anticonvulsants
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Dermatology
Year:
2007
Document type:
Article