Effects of Chitosan on the Differentiation of MDPC-23 Cells
International Journal of Oral Biology
; : 91-97, 2010.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-209528
Responsible library:
WPRO
ABSTRACT
The effects of chitosan upon the experimentally induced differentiation of MDPC-23 cells, derived from mouse dental papilla cells, were investigated by RT-PCR, observations of cell morphology and Alizaline red-S staining. Chitosan was found to significantly increase and accelerate the expression of ALP mRNA but decrease the ColI transcript levels, as compared with the control, in a time-dependent manner during the differentiation of MDPC-23 cells. Chitosan also significantly downregulated ON mRNA expression and accelerated mineralization in differentiating MDPC-23 cells. These results suggest that chitosan facilitates odontoblast differentiation and mineralization and may have potential clinical applications as a dentin regeneration material.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
RNA, Messenger
/
Dental Papilla
/
Dentin
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Chitosan
/
Odontoblasts
Limits:
Animals
Language:
Korean
Journal:
International Journal of Oral Biology
Year:
2010
Document type:
Article