HPV Genotyping in Squamous Cell Carcinoma of Upper Aerodigestive Tract
Korean Journal of Pathology
; : 483-487, 2010.
Article
in En
| WPRIM
| ID: wpr-209652
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Smoking and alcohol consumption are the main risk factors for squamous cell carcinoma of the upper aerodigestive tract (SCCUAT). However, human papillomavirus (HPV) has been etiologically linked with tonsillar squamous cell carcinoma (TSCC). Therefore, we investigated the etiologic role of HPV in the context of SCCUAT in Korea. METHODS: Archival paraffin block samples from 136 cases previously diagnosed as SCCUAT were randomly selected. A commercial HPV DNA chip was used for HPV genotyping. RESULTS: One hundred and seventeen cases were available after checking beta-globin (47 cases of tonsil and 70 of non-tonsil). A HPV-positive result (HPV 16 and 18) occurred in 13 cases of SCCUAT, and 12 cases were tonsil (25.5%, 12/47). Among the 12 HPV-positive patients with TSCC, nine were non-smokers and non-drinkers. Most HPV-negative patients with TSCC had a history of alcohol drinking and smoking (32/35, 91.4%). HPV infection status was not significantly associated with histological grade, clinical stage, or survival in patients with TSCC. CONCLUSIONS: HPV infection was significantly higher in patients with TSCC among those with SCCUAT. HPV may be independent risk factor in development of TSCC, such as smoking and alcohol drinking.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Paraffin
/
Smoke
/
Palatine Tonsil
/
Alcohol Drinking
/
Carcinoma, Squamous Cell
/
Smoking
/
Risk Factors
/
Oligonucleotide Array Sequence Analysis
/
Beta-Globins
/
Korea
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Korean Journal of Pathology
Year:
2010
Document type:
Article