Polymeric Gene Delivery for Diabetic Treatment
Diabetes & Metabolism Journal
; : 317-326, 2011.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-210390
Responsible library:
WPRO
ABSTRACT
Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plasmids
/
Polyethylene Glycols
/
Polylysine
/
Polymers
/
DNA
/
RNA, Messenger
/
Mice, Inbred NOD
/
Interleukin-10
/
Transplants
/
RNA, Small Interfering
Limits:
Animals
Language:
English
Journal:
Diabetes & Metabolism Journal
Year:
2011
Document type:
Article
