Regulation of Th2 Cell Immunity by Dendritic Cells
Immune Network
; : 1-12, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-211463
Responsible library:
WPRO
ABSTRACT
Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell lineage commitment. In this regard, immune cells other than dendritic cells, such as basophils and innate lymphoid cells, have been suggested as Th2 cell inducers. More recently, multiple independent researchers have shown that specialized subsets of dendritic cells mediate Th2 cell responses. This review will discuss the current understanding related to the regulation of Th2 cell responses by dendritic cells and other immune cells.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Helminthiasis
/
Neglected Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Basophils
/
Dendritic Cells
/
Lymphocytes
/
Interleukin-4
/
Th2 Cells
/
Th1 Cells
/
Th17 Cells
/
Helminths
Limits:
Humans
Language:
English
Journal:
Immune Network
Year:
2016
Document type:
Article