Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult
Yonsei Medical Journal
; : 791-796, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-211904
Responsible library:
WPRO
ABSTRACT
A 31-year-old Korean male presented with altered consciousness and severe headache. Brain MRI delineated focal leptomeningeal enhancement without any intracerebral lesions. Diagnosis was made based on a brain biopsy showing anaplastic large cell lymphoma (ALCL), immunohistochemical stains revealing positivity for anaplastic lymphoma kinase (ALK) and an absence of involvement in any other organs; specifically, the primary central nervous system ALK+ALCL. Complete remission was achieved following 5 cycles of systemic chemotherapy with a high dose of Methotrexate and a simultaneous 7 cycles of intrathecal triple chemotherapy. Diagnosis of primary leptomeningeal ALK+ALCL is challenging given its rarity and non-specific symptoms along with non-pathognomonic radiologic findings. We present the first case of primary leptomeningeal ALK-positive ALCL where the clinical course, pathologic characteristics and treatment modality are described as well as a review of literature.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Biopsy
/
Brain
/
Immunohistochemistry
/
Receptor Protein-Tyrosine Kinases
/
Lymphoma, Large-Cell, Anaplastic
/
Diagnosis, Differential
/
Meningeal Neoplasms
/
Antineoplastic Agents
Type of study:
Diagnostic study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2013
Document type:
Article