Desflurane-induced hemodynamic changes in patients with diabetic cardiovascular autonomic neuropathy / 대한마취과학회지
Korean Journal of Anesthesiology
; : 560-565, 2009.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-213800
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Diabetic cardiovascular autonomic neuropathy (CAN) causes perioperative cardiovascular instability. A rapid increase in the desflurane concentration induces tachycardia and hypertension (HTN). This study examined the effects of the cardiovascular response to desflurane on patients with diabetic CAN.METHODS:
Forty diabetes mellitus (DM) patients with CAN were divided two groups one with HTN (DM+HTN group, n = 17) and one without HTN (DM group, n = 23). The control group (n = 20) was composed of healthy patients without DM or HTN. In each group, the concentration of desflurane inspired was increased abruptly to 12.0 vol% 2 minutes after a thiopental injection. The target was to produce an end-tidal concentration of desflurane of 10.0 vol%, which was maintained until the end of the study by adjusting the vaporizer dial setting. The heart rate (HR), mean arterial pressure (MAP), and cardiac index (CI) were measured.RESULTS:
The HR, MAP and CI increased significantly in all three groups when compared with the baseline (P<0.05). Additionally, the HR and MAP showed did not differ among the three groups at any of sampling times. However, the CI of the DM group and the DM+HTN group differed when compared with the control group at 90 and 120 seconds after intubation (P<0.05).CONCLUSIONS:
In diabetic patients with CAN, the hemodynamic responses to a rapid increase in desflurane concentration are similar to those in non-diabetic patients before endotracheal intubation. However, after endotracheal intubation, increments in CI are blunted in diabetic patients with CAN.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Tachycardia
/
Thiopental
/
Nebulizers and Vaporizers
/
Diabetes Mellitus
/
Arterial Pressure
/
Heart Rate
/
Hemodynamics
/
Hypertension
/
Intubation
/
Intubation, Intratracheal
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2009
Document type:
Article