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A Randomized, Open-Label, Multicenter Trial of Topical Tacrolimus for the Treatment of Pruritis in Patients with Atopic Dermatitis
Annals of Dermatology ; : 144-150, 2012.
Article in English | WPRIM (Western Pacific) | ID: wpr-214980
Responsible library: WPRO
ABSTRACT

BACKGROUND:

Pruritis caused by atopic dermatitis (AD) is not always well controlled by topical corticosteroid therapy, but use of tacrolimus often helps to soothe such intractable pruritis in clinical settings.

OBJECTIVE:

To determine the anti-pruritic efficacy of topical tacrolimus in treating AD in induction and maintenance therapy.

METHODS:

Prior to the study, patients were randomly allocated into two groups, induction therapy followed by tacrolimus monotherapy maintenance, and induction therapy followed by emollient-only maintenance. In the induction therapy, the patients were allowed to use topical tacrolimus and emollients in addition to a low dose (<10 g/week) of topical steroids. Patients showing relief from pruritis were allowed to proceed to maintenance therapy. Recurrence of pruritis in maintenance therapy was examined as a major endpoint.

RESULTS:

Two-thirds of patients (44/68; 64.7%) showed relief from pruritis after induction therapy. Pruritis recurred in 23.8% (5/21) of the tacrolimus monotherapy group and in 100% (21/21) of the emollient group during maintenance period, a difference that was statistically significant.

CONCLUSION:

Use of topical tacrolimus is effective in controlling pruritis of AD compared to emollient.
Subject(s)

Full text: Available Database: WPRIM (Western Pacific) Main subject: Pruritus / Recurrence / Steroids / Tacrolimus / Dermatitis, Atopic / Emollients Type of study: Controlled clinical trial Limits: Humans Language: English Journal: Annals of Dermatology Year: 2012 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Pruritus / Recurrence / Steroids / Tacrolimus / Dermatitis, Atopic / Emollients Type of study: Controlled clinical trial Limits: Humans Language: English Journal: Annals of Dermatology Year: 2012 Document type: Article
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