Eradication rate of one-week triple therapy for peptic ulcer with Helicobacter pylori and clinical characteristics of patients with failed eradication

ABSTRACT

BACKGROUND: The decisive factors influencing the eradication of H. pylori still remain unclear. It was our aim to assess H.pylori eradication rate with proton pump inhibitor based triple therapy and investigate the clinical characteristics and endoscopic factors. METHODS: We investigated 106 male patients with H.pylori- positive peptic ulcer. The patients were treated with a 1-week regimen composed of omeprazole, amoxicillin and clarithromycin. THe success of the treatment was evaluated by histology at least 4 weeks after completion of therapy. Endoscopic factor and clinical factors influencing H.pylori eradication were assessed. RESULTS: The overall eradication of H.pylori was successful in 87 of 106 patients (82%). The eradication rate was higher in those who drink or smoke, with gastric ulcer, less than 50 years old but these factors did not significantly influence the outcome of treatment. CONCLUSIONS: H.pylori eradication rate with omeprazole, amoxicillin, and clarithromycin did not differ from other studies. These results suggest that factors such as smoking, drinking, age and ulcer site did not influence the eradication rate of H.pylpori.