ChimerDB - Database of Chimeric Sequences in the GenBank
Genomics & Informatics
; : 61-66, 2004.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-217510
Responsible library:
WPRO
ABSTRACT
Fusion proteins resulting from chimeric sequences are excellent targets for therapeutic drug development. We developed a database of chimeric sequences by examining the genomic alignment of mRNA and EST sequences in the GenBank. We identified 688 chimeric mRNA and 20,998 chimeric EST sequences. Including EST sequences greatly expands the scope of chimeric sequences even though it inevitably accompanies many artifacts. Chimeric sequences are clustered according to the ECgene ID so that the user can easily find chimeric sequences related to a specific gene. Alignments of chimeric sequences are displayed as custom tracks in the UCSC genome browser. ChimerDB, available at http//genome.ewha.ac.kr/ECgene/ChimerDB/, should be a valuable resource for finding drug targets to treat cancers.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Translocation, Genetic
/
RNA, Messenger
/
Genome
/
Artifacts
/
Trans-Splicing
/
Databases, Nucleic Acid
Type of study:
Prognostic study
Language:
English
Journal:
Genomics & Informatics
Year:
2004
Document type:
Article