The Anti-inflammatory Effect of Rosiglitazone on Renal Injury in Sepsis Model / 대한신장학회잡지
Korean Journal of Nephrology
; : 526-536, 2005.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-218842
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Agonists of the peroxisome proliferator-activated receptor gamma may help to regulate inflammation by modulating the production of inflammatory mediators and adhesion molecules. The purpose of this study was to determine the anti- inflammatory effects of rosiglitazone on renal injury in sepsis model.METHODS:
In lipopolysaccharide (LPS)-induced mouse sepsis, we examined the effect of rosiglitazone on LPS-induced overproduction of inflammatory mediators, on the expression of adhesion molecules, on the infiltration of inflammatory cells and on renal function.RESULTS:
Rosiglitazone significantly decreased serum tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta levels during sepsis. The levels of blood urea nitrogen and creatinine were significantly lower in mice pretreated with rosiglitazone than that in LPS-treated mice. Rosiglitazone reduced the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in renal tissue of LPS-treated mice. Pretreatment with rosiglitazone reduced the infiltration of macrophages/ monocytes in renal tissue.CONCLUSION:
These results indicate that pretreatment with rosiglitazone attenuated the production of TNF-alpha and IL-1beta and reduced adhesion molecule expression and infiltration of inflammatory cells in renal tissue of LPS-treated mice. Therefore, rosiglitazone may have a protective effect in maintaining renal function and reducing mortality and morbidity in sepsis.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Kidney, Renal Pelvis and Ureter Cancer
Database:
WPRIM (Western Pacific)
Main subject:
Blood Urea Nitrogen
/
Monocytes
/
Mortality
/
Interleukins
/
Tumor Necrosis Factor-alpha
/
Sepsis
/
Intercellular Adhesion Molecule-1
/
Vascular Cell Adhesion Molecule-1
/
Creatinine
/
PPAR gamma
Type of study:
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2005
Document type:
Article