Early monitoring for detection of antituberculous drug-induced hepatotoxicity
The Korean Journal of Internal Medicine
; : 65-72, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-220501
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
We investigated the time of onset of antituberculous drug-induced hepatotoxicity (ADIH) and related characteristics.METHODS:
Adult patients (n = 1,031) treated with first-line antituberculous drugs between February 2009 and January 2013 were enrolled.RESULTS:
Of the 1,031 patients, 108 patients (10.5%) developed ADIH a mean of 39.6 +/- 43.7 days after treatment initiation. Twenty-eight patients (25.9%) developed ADIH within 7 days, 73 (67.6%) within 30 days, and the rest after 30 days. The 30-day group. In subgroup analysis, the 40 IU/L (odds ratio [OR], 2.995; 95% confidence interval [CI], 1.580 to 5.680; p = 0.001) and presence of anti-hepatitis C virus (OR, 4.204; 95% CI, 1.822 to 9.700, p = 0.001) were independent risk factors for development of ADIH.CONCLUSIONS:
Approximately 70% of the cases of ADIH occurred in the first month of antituberculous treatment, and were associated with continuation of the first-line drug regimen.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Tuberculosis
Database:
WPRIM (Western Pacific)
Main subject:
Aspartate Aminotransferases
/
Time Factors
/
Biomarkers
/
Chi-Square Distribution
/
Logistic Models
/
Odds Ratio
/
Multivariate Analysis
/
Predictive Value of Tests
/
Retrospective Studies
/
Risk Factors
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2016
Document type:
Article