Significance of Peritoneal Protein Clearance in Peritoneal Dialysis Patients / 대한신장학회지
Korean Journal of Nephrology
; : 638-646, 2011.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-220803
Responsible library:
WPRO
ABSTRACT
PURPOSE:
It has been reported recently that peritoneal protein clearance (Pcl) is a marker of endothelial dysfunction and cardiovascular disease in peritoneal dialysis patients. We evaluated whether baseline or longitudinal follow-up Pcl is a factor to consider in predicting the outcome in peritoneal dialysis patients for the follow-up period.METHODS:
Patients who initiated continuous ambulatory peritoneal dialysis at our center from September 1994 to January 2006 and had a baseline peritoneal equilibration test, measurement of dialysis adequacy, and 24-h dialysate Pcl (24hr dialysate protein loss/ [serum albumin/0.4783]) were included. Demography, comorbidities, and biochemical data were retrospectively collected. Follow-up was until death or the end of the period studied (November 2009).RESULTS:
A total of 203 patients (56% men, mean age 55.0+/-12.5; 55.2% with diabetes; 22.2% with cardiovascular disease) were included. The mean follow up period was 38 months (3-170 months). Baseline Pcl was 128.2 ml/day. Follow up data of Pcl were not changed from baseline period. Cox's analysis revealed the predictors of mortality (and technical failure) were age and diabetes mellitus but not dialysate/plasma creatinine ratio (D/Pcr) and Pcl. On multivariate analysis, Pcl was negatively correlated with serum albumin and triglyceride and positively correlated with D/Pcr and peritoneal creatinine clearance.CONCLUSION:
Our study showed that the changes in Pcl over time were not significant from baseline up to 53 months. Neither baseline nor mean Pcl during the follow-up period were independent predictors for technical or patient survival.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
/
Endocrine System Diseases
/
Other Malignant Neoplasms
Database:
WPRIM (Western Pacific)
Main subject:
Ascitic Fluid
/
Serum Albumin
/
Cardiovascular Diseases
/
Comorbidity
/
Demography
/
Multivariate Analysis
/
Retrospective Studies
/
Follow-Up Studies
/
Peritoneal Dialysis
/
Peritoneal Dialysis, Continuous Ambulatory
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Aspects:
Social determinants of health
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2011
Document type:
Article