Liver Transplantation for Metabolic Liver Disease: Experience at a Living Donor Dominant Liver Transplantation Center / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
; : 48-54, 2015.
Article
in En
| WPRIM
| ID: wpr-222172
Responsible library:
WPRO
ABSTRACT
PURPOSE: Metabolic liver disease (MLD) often progresses to life-threatening conditions. This study intends to describe the outcomes of liver transplantation (LTx) for MLD at a living donor-dominant transplantation center where potentially heterozygous carrier grafts are employed. METHODS: We retrospectively evaluated the medical records of 54 patients with MLD who underwent LTx between November 1995 and February 2012 at Asan Medical Center in Seoul, Korea. The cumulative graft and patient survival rates were analyzed according to patient age, and living or deceased donor LTx. Recurrence of the original disease was also investigated. RESULTS: The post-transplant cumulative patient survival rates at one, five, and 10 years were 90.7%, 87.5% and 87.5%, and the graft survival rates were 88.8%, 85.5%, and 85.5%, respectively. There were no differences in the patient survival rates according to the recipient age, human leukocyte antigen matching, and living or deceased donor LTx. There were also no differences in the patient survival rates between the MLD and the non-MLD groups for children. Recurrence of the original metabolic disease was not observed in any patient during the follow-up period. CONCLUSION: Our results suggest that the living donor-dominant transplantation program is well-tolerated in MLD without recurrence of the original MLD using all types of transplantation.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Recurrence
/
Tissue Donors
/
Medical Records
/
Survival Rate
/
Retrospective Studies
/
Follow-Up Studies
/
Liver Transplantation
/
Living Donors
/
Transplants
/
Seoul
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Child
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Pediatric Gastroenterology, Hepatology & Nutrition
Year:
2015
Document type:
Article