Hemophagocytic Lymphohistiocytosis Manifesting as a Purpuric Patch / 대한피부과학회지
Korean Journal of Dermatology
; : 421-424, 2014.
Article
in Ko
| WPRIM
| ID: wpr-222292
Responsible library:
WPRO
ABSTRACT
Hemophagocytic lymphohistiocytosis (HLH) is a fatal, systemic inflammatory syndrome that characteristically presents hemophagocytic histiocytes infiltrating into various organs. Common features of HLH are abrupt onset of high fever, malaise, lymphadenopathy, hepatosplenomegaly, and abnormal laboratory findings including pancytopenia, hypertriglyceridemia, hypofibrinogenemia, and high ferritin levels. Cutaneous manifestations, which occur in 6~65% of patients, can develop at any moment in the clinical course of the syndrome. Most skin eruptions in HLH patients are generalized, transient maculopapular rashes. We describe an HLH patient who first manifested cutaneous symptoms as a large purpuric patch on her thigh. A skin biopsy found high levels of hemophagocytic histiocytes.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Pancytopenia
/
Purpura
/
Skin
/
Thigh
/
Biopsy
/
Hypertriglyceridemia
/
Lymphohistiocytosis, Hemophagocytic
/
Exanthema
/
Ferritins
/
Fever
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Dermatology
Year:
2014
Document type:
Article