A case of rifampicin-induced interstitial pneumonitis / 대한내과학회지
Korean Journal of Medicine
; : 592-596, 2008.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-222963
Responsible library:
WPRO
ABSTRACT
Rifampicin is a powerful agent for the treatment of pulmonary tuberculosis. However, it may induce several adverse effects, including rare cases of lung toxicity. Here, we report a case of rifampicin-induced interstitial pneumonitis. A 57-year-old woman diagnosed with cerebellar tuberculoma developed progressive dyspnea after the 5th day of anti-tuberculosis medication. Chest X-ray revealed newly developed ground glass opacities on both lower lung fields. Drug-induced pneumonitis was suspected and all anti-tuberculosis medications were halted. Transbronchial lung biopsy was consistent with desquamative interstitial pneumonitis. After clinical improvement, a rechallenge test with each anti-tuberculosis medication was attempted. No primary anti-tuberculosis drug except rifampicin triggered recurrence of symptoms, supporting a diagnosis of rifampicin-induced interstitial pneumonitis. Clinicians should be aware of this rare, but serious, side effect of rifampicin treatment.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Tuberculosis
Database:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Recurrence
/
Rifampin
/
Thorax
/
Tuberculoma
/
Tuberculosis
/
Tuberculosis, Pulmonary
/
Biopsy
/
Lung Diseases, Interstitial
/
Dyspnea
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2008
Document type:
Article