Outcome and Current Status of Therapeutic Hypothermia Following Out-of-hospital Cardiac Arrest in Korea from the Korea Hypothermia Network Registry
Journal of the Korean Society of Emergency Medicine
; : 747-755, 2014.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-223353
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Therapeutic hypothermia (TH) has become a standard strategy for reducing brain damage in the postresuscitation period. The aim of this study is to investigate the outcomes and current performance of TH with out-of-hospital cardiac arrest (OHCA) survivors through the Korean hypothermia network (KORHN) registry.METHODS:
We used the KORHN registry, a web-based, multicenter registry that includes 24 participating hospitals throughout the Republic of Korea. Adult comatose OHCA survivors treated with TH from 2007 to 2012 were included. The primary outcomes were neurologic outcome at hospital discharge and in-hospital mortality. The secondary outcomes were TH performance and adverse events during TH.RESULTS:
A total of 930 patients were included; of these, 556 (59.8%) patients survived to discharge and 249 (26.8%) were discharged with good neurologic outcomes. The median time from return of spontaneous circulation (ROSC) to the start of TH was 101 (interquartile range (IQR) 46-200) minutes. The induction, maintenance, and rewarming durations were 150 (IQR 80-267) minutes, 1440 (IQR 1290-1440) minutes, and 708 (IQR 420-900) minutes, respectively. The time from the ROSC to coronary angiography was 1,045 (IQR 121-12,051) hours. Hyperglycemia (46.3%) was the most frequent adverse event.CONCLUSION:
Over one quarter of OHCA survivors (26.8%) were discharged with good neurologic outcome. TH performance was managed appropriately in terms of the factors related to the timing of TH, which were the start time for cooling and the rewarming duration.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
/
Endocrine System Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Brain
/
Registries
/
Hospital Mortality
/
Coronary Angiography
/
Survivors
/
Rewarming
/
Coma
/
Republic of Korea
/
Out-of-Hospital Cardiac Arrest
/
Hyperglycemia
Type of study:
Controlled clinical trial
Limits:
Adult
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of the Korean Society of Emergency Medicine
Year:
2014
Document type:
Article