The Effects of Propofol and Thiopental Continuous Infusion on Serum Potassium Disturbances in Neurosurgical Patients
Journal of Korean Neurosurgical Society
; : 197-203, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-223800
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
The potassium disturbance associated with thiopental continuous infusion in neurosurgical patients is well known. However, the effect of propofol continuous infusion on serum potassium levels has not been investigated extensively.METHODS:
We reviewed the medical records of 60 consecutive patients who received coma therapy or deep sedation for intracranial pressure control using either thiopental or propofol between January 2010 and January 2012.RESULTS:
The overall incidence of hypokalemia (K5.0 mmol/L, 32.4% vs. 4.3%, p=0.010) and the peak potassium concentration (4.8 mmol/L vs. 4.2 mmol/L, p=0.037) after the cessation of therapy were higher in thiopental group. On multivariate analysis, thiopental [8.82 (1.00-77.81); p=0.049] and duration of continuous infusion [1.02 (1.00-1.04); p=0.016] were associated with rebound hyperkalemia once therapy was discontinued.CONCLUSION:
Propofol was less frequently associated with moderate to severe hypokalemia after induction and rebound hyperkalemia following the cessation of continuous infusion than thiopental.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Potassium
/
Thiopental
/
Intracranial Pressure
/
Propofol
/
Medical Records
/
Incidence
/
Multivariate Analysis
/
Coma
/
Intracranial Hypertension
/
Deep Sedation
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2015
Document type:
Article