Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APCMIN Mouse Model
Journal of Cancer Prevention
; : 135-146, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-226322
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Anthocyanin-rich foods and preparations have been reported to reduce the risk of life-style related diseases, including cancer. The SL222 sweet potato, a purple-fleshed cultivar developed in New Zealand, accumulates high levels of anthocyanins in its storage root.METHODS:
We examined the chemopreventative properties of the SL222 sweet potato in the C57BL/6J-APC(MIN/+) (APC(MIN)) mouse, a genetic model of colorectal cancer. APC(MIN) and C57BL/6J wild-type mice (n=160) were divided into four feeding groups consuming diets containing 10% SL222 sweet potato flesh, 10% SL222 sweet potato skin, or 0.12% ARE (Anthocyanin rich-extract prepared from SL222 sweet potato at a concentration equivalent to the flesh-supplemented diet) or a control diet (AIN-76A) for 18 weeks. At 120 days of age, the mice were anaesthetised, and blood samples were collected before the mice were sacrificed. The intestines were used for adenoma enumeration.RESULTS:
The SL222 sweet potato-supplemented diets reduced the adenoma number in the APC(MIN) mice.CONCLUSIONS:
These data have significant implications for the use of this sweet potato variant in protection against colorectal cancer.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 9: Noncommunicable diseases and mental health
Database:
WPRIM (Western Pacific)
Main subject:
Skin
/
Colorectal Neoplasms
/
Adenoma
/
Ipomoea batatas
/
Diet
/
Intestines
/
Anthocyanins
/
Models, Genetic
/
New Zealand
Limits:
Animals
Country/Region as subject:
Oceania
Language:
English
Journal:
Journal of Cancer Prevention
Year:
2017
Document type:
Article