A case of vincristine-induced polyneuropathy in an patient with acute leukemia / 대한내과학회지
Korean Journal of Medicine
; : 611-616, 2009.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-227730
Responsible library:
WPRO
ABSTRACT
When neurological symptoms occur during the treatment of acute lymphoblastic leukemia, the differential diagnosis includes a leukemic infiltration of the nervous system, drug toxicity, infection, and other neurological disorders. We describe a 16-year-old girl with acute lymphoblastic leukemia that appeared to be complicated by vincristine-induced peripheral and cranial polyneuropathy after induction chemotherapy. She presented with right ptosis six weeks after the first dose of vincristine, and her neurological symptoms progressed to peripheral polyneuropathy. She recovered from these neurological symptoms over the next three months. Leukemic involvement of the nervous system and other neurological disorders could be excluded as potential causes of the neurological symptoms. This report shows that vincristine-induced neurotoxicity should be considered as a cause of cranial neuropathy that develops during the treatment of acute lymphoblastic leukemia.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polyneuropathies
/
Vincristine
/
Leukemia
/
Leukemic Infiltration
/
Cranial Nerve Diseases
/
Diagnosis, Differential
/
Drug-Related Side Effects and Adverse Reactions
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Induction Chemotherapy
/
Nervous System
Type of study:
Diagnostic study
Limits:
Adolescent
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2009
Document type:
Article