Systemic lupus erythematosus complicated with cerebral venous sinus thrombosis: a report of two cases
Journal of Korean Medical Science
; : 351-354, 2001.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-228339
Responsible library:
WPRO
ABSTRACT
A rare manifestation of systemic lupus erythematosus (SLE) is cerebral venous sinus thrombosis (CVST), in which early diagnosis and aggressive therapy are of prime importance for favorable outcome. The pathogenesis of CVST is largely unknown, but it is thought to be caused by cerebral vasculitis, antiphospholipid antibodies or other conditions associated with enhanced coagulability. We describe two cases of SLE with CVST which were not associated with antiphospholipid antibodies. Both cases were treated with immunosuppressants (intravenous methylprednisolone and cyclophosphamide pulse therapy) and anticoagulant drugs (heparin and subsequent maintenance therapy with warfarin). There was a marked improvement of neurologic symptoms with the disappearance of thrombus in a follow-up MRI. The possibility of CVST should be considered in any patients with SLE who show neuropsychiatric manifestations.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Sinus Thrombosis, Intracranial
/
Warfarin
/
Brain
/
Methylprednisolone
/
Magnetic Resonance Imaging
/
Heparin
/
Treatment Outcome
/
Cyclophosphamide
/
Glucocorticoids
/
Immunosuppressive Agents
Type of study:
Screening study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2001
Document type:
Article