Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues
Journal of Korean Medical Science
; : 313-316, 2001.
Article
in En
| WPRIM
| ID: wpr-228346
Responsible library:
WPRO
ABSTRACT
The effects of thyroid hormone on hepatic and gastric alcohol dehydrogenase (ADH) activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with thyroxine (1 mg/kg, po) for 14 days. Whereas hepatic ADH activity in thyroxine-treated rats decreased by 61.3% of control rats (26.4 vs 43.2, p<0.001), gastric ADH activity increased by 262.9% of control rats (4.9 vs 1.9, p<0.001). As for the activities of the lung and kidney, thyroxine treatment did not produce any statistically significant changes. These data suggest that thyrotoxicosis causes a decrease of hepatic alcohol metabolism, and that the increase of gastric ADH activity in thyrotoxic rats can partly restore the first-pass metabolism of ethanol.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Stomach
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Thyroxine
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Alcohol Dehydrogenase
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Thyrotoxicosis
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Rats, Sprague-Dawley
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Gastric Mucosa
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Kidney
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Liver
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Lung
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Animals
Limits:
Animals
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2001
Document type:
Article