Serial Determinations of Serum Squamous Cell Carcinoma Antigen (SCC) during Radiotherapy for Uterine Cervix Cancer / 대한방사선종양학회지
The Journal of the Korean Society for Therapeutic Radiology and Oncology
; : 136-141, 2001.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-228680
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To evaluate the significance of serum SCC for the monitoring of treatment response and the early detection of distant metastasis during radiotherapy (RT). MATERIALS ANDMETHODS:
In 13 patients with histologically proven primary squamous cell carcinoma of uterine cervix, serum SCC values were checked in pre-RT point, weekly during RT, and in post-RT point.RESULTS:
In 4 of 13 cases, metastasis appeared at the end of external RT, so that intracavitary radiation couldn't be performed. Of these 4 cases, 3 with elevated pre-RT SCC level, who resulted in lung metastasis on chest PA at the end of external RT showed decreased post-RT SCC value despite of metastasis. Of all 10 cases with elevated pre-RT SCC value (including 3 with metastasis at the end of external RT), SCC value was higher than pre-RT value in 7 at 9 Gy and the difference was statistically significant. At 18 Gy, SCC was higher in 4 and lower in 6 than pre-RT value. After 18 Gy, SCC value decreased continuously to the end of RT in all 10 cases.CONCLUSION:
During RT, SCC value increased initially at 9 Gy. To 18 Gy, SCC value decreased to the nearly same with pre-RT value. After 18 Gy, to the end of RT, SCC value decreased continuously and normalized in completely responded cases. In cases with appearance of lung metastasis, SCC value also decreased with the disappearance of main mass of uterine cervix despite of metastasis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Radiotherapy
/
Thorax
/
Carcinoma, Squamous Cell
/
Uterine Cervical Neoplasms
/
Cervix Uteri
/
Lung
/
Neoplasm Metastasis
Type of study:
Screening study
Limits:
Female
/
Humans
Language:
Korean
Journal:
The Journal of the Korean Society for Therapeutic Radiology and Oncology
Year:
2001
Document type:
Article