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Immunogenicity of sabin inactivated poliovirus vaccine induced by diphtheria-tetanus-acellular pertussis and Sabin inactivated poliovirus combined vaccine / 中华实验和临床病毒学杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-231151
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>In order to search the preparation process and optimazing dosage ratio of adsorbed diphtheria-tetanus-acellular pertussis and sabin inactivated poliovirus combined vaccine (DTaP-sIPV), the neutralizing antibody titers of IPV induced by different concentration of DTaP-sIPV were investigated on rats.</p><p><b>METHODS</b>Two batches of DTaP-sLPV were produced using different concentration of sIPV and the quality control was carried. Together with sabin-IPV and DTaP-wIPV ( boostrix-polio, GSK, Belgium) as control group, the DTaP-sIPV were administrated on three-dose schedule at 0, 1, 2 month on rats. Serum sample were collected 30 days after each dose and neutralizing antibody titers against three types poliovirus were determined using micro-neutralization test.</p><p><b>RESULTS</b>Two batches of prepared DTaP-sIPV and control sLPV were according to the requirement of Chinese Pharmacopoeia (Volume III, 2005 edition) and showed good stability. The seropositivity rates were 100% for sabin inactivated poliovirus antigen in all groups. The GMTs (Geometric mean titers) of neutralizing antibodies against three types poliovirus increased.</p><p><b>CONCLUSION</b>The prepared DTaP-sIPV was safe, stable and effective and could induced high level neutralizing antibody against poliovirus on rats.</p>
Subject(s)
Full text: Available Database: WPRIM (Western Pacific) Main subject: Poliovirus Vaccine, Inactivated / Rats, Wistar / Vaccines, Combined / Diphtheria-Tetanus-acellular Pertussis Vaccines / Allergy and Immunology / Antibodies, Viral Limits: Animals Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2011 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Poliovirus Vaccine, Inactivated / Rats, Wistar / Vaccines, Combined / Diphtheria-Tetanus-acellular Pertussis Vaccines / Allergy and Immunology / Antibodies, Viral Limits: Animals Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2011 Document type: Article
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