Prognostic analysis of 336 patients with chronic severe hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 458-460, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-231219
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the risk factors related to outcome of chronic severe hepatitis B.</p><p><b>METHODS</b>A total of 336 consecutive patients with chronic severe hepatitis B (CSHB) were analysed retrospectively. According to the outcome, objects were divided into survival group (n = 137) and death group(n = 199), then to observe the differences between them in respect to age, sex, family history, prothrombin activity (PTA), complications including ascites, infection, electrolyte disturbance, upper gastrointestinal bleeding, hepatic encephalopathy, hepatorenal syndrome and the corresponding quantity of complications in each individual, antivirus therapy, artificial liver support system (ALSS) therapy, and alprostadil therapy. Finally, risk factors related to prognosis were selected by stepwise Logistic regression analyse.</p><p><b>RESULTS</b>In univariate analyse, significant differences between the two groups were found related to age, PTA, complications and its quantity (P < 0.01 for all), and antivirus therapy (P < 0.05) rather than sex, family history and treatment of ALSS or alprostadil. Logistic regression revealed that risk factors comprised of PTA and quantity of complications, antivirus therapy was the only protective factor.</p><p><b>CONCLUSION</b>A numbers of factors including age, PTA, complications and its quantity, and antivirus therapy affect the prognosis of CSHB, among which, antivirus therapy can reduce the death rate.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.3 End transmission of communicable diseases
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SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Target 3.3: End transmission of communicable diseases
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Hepatitis
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Digestive System Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
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Logistic Models
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Retrospective Studies
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Risk Factors
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Treatment Outcome
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Hepatitis B, Chronic
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Diagnosis
Type of study:
Diagnostic study
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Etiology study
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Observational study
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Prognostic study
Limits:
Adult
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2010
Document type:
Article