Clinicopathological characteristics and potential etiologies of neonatal spontaneous gastric perforation / 中华儿科杂志
Chinese Journal of Pediatrics
; (12): 779-782, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-231240
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the etiology and clinicopathological features of neonatal spontaneous gastric perforation.</p><p><b>METHODS</b>The clinical data of 15 cases with neonatal gastric perforation seen from 2001 to 2009 were retrospectively analyzed. Immunohistochemical staining was adopted for all the cases.</p><p><b>RESULTS</b>The typical clinical manifestations of this disease were vomiting, abdominal distention and respiratory distress. Abdominal orthostatic X-ray showed free gas under diaphragm and seroperitoneum. In most of the cases the stomach perforation occurred at the greater curvature. Eight of the cases died in this group, the mortality was 53.33%. Six of the deaths occurred within 1 day after birth with symptoms. There were thinning and defect of stomach wall muscle and interstitial cells of Cajal (ICC) reduction as demonstrated by microscope.</p><p><b>CONCLUSIONS</b>Spontaneous neonatal gastric perforation is associated with abnormal gastric wall structure and reduction of ICC. Prognosis is closely related to the time of onset and the timely surgical operation.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
/
Digestive System Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Stomach Rupture
/
Retrospective Studies
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Pediatrics
Year:
2010
Document type:
Article