Application of quantitative evaluation on multicomponent drug interaction in anti-HIV research / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 1665-1667, 2013.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-231624
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To quantitatively evaluate mutual relations of 4 component drugs in anti-HIV action.</p><p><b>METHODS</b>The effect of TCM four components on cell growth was detected using MTT assay. The antiviral effects of 4 components were observed at the maximal nonvenomous dose. The combination index (CI) value of combined two or four components were calculated using median-effect principle. The mutual relations of two or four components for antiviral actions were assessed using CI.</p><p><b>RESULTS</b>Synergism was dominant in combination of A and B, and the effect was dose-dependent. Antagonism was dominant in combination of C and D, and the effect was dose-dependent. But the combination of A, B, C, and D was synergistic when the inhibition rate was over 10%.</p><p><b>CONCLUSION</b>Median-effect principle can be used to quantitatively assess the anti-HIV effect of four components.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Pharmacology
/
Cell Line
/
HIV-1
/
Dose-Response Relationship, Drug
/
Drug Antagonism
/
Drug Synergism
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2013
Document type:
Article