Immunogenecity of combined hepatitis A and B vaccine / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 155-159, 2004.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-231969
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the immunogenicity of combined hepatitis A and B vaccine (HAB).</p><p><b>METHODS</b>The combined HAB vaccine was prepared and different concentrations of HAB were administered on mice in week 0, 4 and 24, and then we tested the antibodies to both hepatitis A virus and B virus. After the first injection, we tested the hepatitis A antigen-induced and hepatitis B surface antigen-induced stimulation indices in spleen monocyte as well as changes of CD4+ and CD8+ cell numbers.</p><p><b>RESULTS</b>The serum antibody positive rates were 100% in all three groups, and the antibody induced by HAB vaccine were earlier than by monovalent vaccine. The hepatitis A antibody and hepatitis B surface antibody titers after the combined vaccine inoculation were not significantly higher than those after the monovalent vaccine inoculation. On the other hand, after the first injection of the combined vaccine, the hepatitis A antigen-induced and hepatitis B surface antigen-induced stimulation indices in spleen monocyte were detected. The numbers of CD4+ and CD8+ cells increased.</p><p><b>CONCLUSIONS</b>HAB vaccine has reliable immunogenicity.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.3 End transmission of communicable diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Hepatitis
Database:
WPRIM (Western Pacific)
Main subject:
Blood
/
Leukocytes, Mononuclear
/
Random Allocation
/
Vaccination
/
CD4-CD8 Ratio
/
Hepatitis B Vaccines
/
Vaccines, Combined
/
Hepatitis A Vaccines
/
Hepatitis A Antibodies
/
Allergy and Immunology
Limits:
Animals
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2004
Document type:
Article