Progress in the study of allergic disease drugs targeting on IgE/FcepsilonRI signaling pathway / 药学学报
Acta Pharmaceutica Sinica
; (12): 1161-1166, 2011.
Article
in Zh
| WPRIM
| ID: wpr-233018
Responsible library:
WPRO
ABSTRACT
Allergic diseases have become global social health problems. The binding of IgE with its high affinity receptor FcepsilonRI plays a key step in I-type allergy. Recently, more and more key molecules on the IgE/FcepsilonRI signaling transduction pathway were to be the drug candidates against allergic diseases, with in-depth study of FcepsilonRI signal pathway gradually. The main drugs include molecule antibodies, peptides, vaccines, fusion proteins, small molecules, and other drugs related to IgE/FcepsilonRI. The recent progress in the study of mechanisms of representative drugs targeting on IgE/FcepsilonRI signaling pathway was reviewed in this article.
Full text:
1
Database:
WPRIM
Main subject:
Pharmacology
/
Pyrimidines
/
Protein-Tyrosine Kinases
/
Immunoglobulin E
/
Signal Transduction
/
Antibodies, Anti-Idiotypic
/
Receptors, IgE
/
Anti-Allergic Agents
/
Therapeutic Uses
/
Intracellular Signaling Peptides and Proteins
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Document type:
Article