Research progress of zebrafish used in drug metabolism

Qiu-xia CHEN; Su ZENG

Research progress of zebrafish used in drug metabolism / 药学学报

Qiu-xia CHEN; Su ZENG.

Acta Pharmaceutica Sinica ; (12): 1026-1031, 2011.

Article in Chinese | WPRIM (Western Pacific) | ID: wpr-233040

Responsible library: WPRO

ABSTRACT

ABSTRACT

Zebrafish is widely used as a model organism in the process of drug discovery. It expresses drug metabolizing enzymes like cytochrome P450 (CYP450), uridine 5'-diphospho-glucuronosyltransferase (UGT) and nuclear receptors like pregnane X receptor (PXR), aryl hydrocarbon receptor (AHR), etc. This article summarized the profiles of main drug metabolizing enzymes and nuclear receptors, and reviewed the advances on xenobiotics metabolism in zebrafish.

Subject(s)

Animals; Cytochrome P-450 Enzyme System; Metabolism; Embryo, Nonmammalian; Glucuronosyltransferase; Metabolism; Inactivation, Metabolic; Pharmaceutical Preparations; Metabolism; Polychlorinated Dibenzodioxins; Toxicity; Receptors, Aryl Hydrocarbon; Metabolism; Receptors, Cytoplasmic and Nuclear; Metabolism; Receptors, Steroid; Metabolism; Teratogens; Toxicity; Xenobiotics; Metabolism; Zebrafish; Embryology; Metabolism

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Full text: Available Database: WPRIM (Western Pacific) Main subject: Teratogens / Zebrafish / Pharmaceutical Preparations / Inactivation, Metabolic / Xenobiotics / Receptors, Steroid / Embryology / Glucuronosyltransferase / Receptors, Cytoplasmic and Nuclear / Receptors, Aryl Hydrocarbon Limits: Animals Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2011 Document type: Article

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