The value of antimitochondrial antibody and its subtypes in the diagnosis of primary biliary cirrhosis / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 9-11, 2005.
Article
in Zh
| WPRIM
| ID: wpr-233635
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>A study on the value of antimitochondrial antibody (AMA) and its subtypes anti-M2, anti-M4, and anti-M9 in diagnosing primary biliary cirrhosis (PBC).</p><p><b>METHODS</b>Antimitochondrial antibody was detected by indirect immunofluorescence and anti-M2, anti-M4 and anti-M9 by Western blotting. AMA and anti-M2 of 78 PBC patients, of 35 non-PBC hepato-biliary disease patients and 20 healthy controls were studied and anti-M2, anti-M4 and anti-M9 were studied in 30 of the 78 PBC patients.</p><p><b>RESULTS</b>96.2% (75/78) of PBC patients were AMA positive and 94.9% (74/78) of PBC patients were anti-M2 positive. Only three among the 35 non-PBC patients were positive for AMA (one with very low titre). None of the 35 non-PBC patients was anti-M2 positive. AMA and anti-M2 were negative in all the healthy controls. Among the 30 anti-M2 positive patients, 16 patients were anti-M4 positive (16/30, 53.3%) and 4 patients were anti-M9 positive (4/30, 13.3%).</p><p><b>CONCLUSION</b>AMA and its subtypes (special anti-M2) are important sero-immunological markers for the diagnosis of PBC.</p>
Full text:
1
Database:
WPRIM
Main subject:
Autoantibodies
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Blood
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Mitochondria, Liver
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Classification
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Diagnosis
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Allergy and Immunology
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Liver Cirrhosis, Biliary
Type of study:
Diagnostic_studies
Limits:
Female
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Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Hepatology
Year:
2005
Document type:
Article