Vitamin D3 regulates cell viability in gastric cancer and cholangiocarcinoma / 대한해부학회지
Anatomy & Cell Biology
; : 204-209, 2011.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-23478
Responsible library:
WPRO
ABSTRACT
A low serum level of vitamin D has been associated with an increased incidence of gastrointestinal tract cancers. However, the effects of vitamin D3 have not been investigated in gastric cancer and cholangiocarcinoma. In the present study, we found that vitamin D3 treatment significantly suppressed the viability of gastric cancer and cholangiocarcinoma cells. Moreover, vitamin D3 had a synergistic effect with other anti-cancer drugs, such as paclitaxel, adriamycin, and vinblastine, for suppressing cell viability. To determine the underlying mechanism involved in the regulation of viability by vitamin D3, we examined the effects of vitamin D3 on expression of hedgehog signaling target genes, which has been associated with gastric cancer and cholangiocarcinoma. Vitamin D3 treatment decreased the level of mRNA expression of patched1, Gli1, cyclin D1, and Bcl2, suggesting the possibility that vitamin D3 may act through regulation of hedgehog signaling. From the above results, we conclude that vitamin D3 regulates cell viability in gastric cancer and cholangiocarcinoma.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Stomach Neoplasms
/
Vinblastine
/
Vitamin D
/
Vitamins
/
RNA, Messenger
/
Doxorubicin
/
Cell Survival
/
Incidence
/
Paclitaxel
/
Cholangiocarcinoma
Type of study:
Incidence study
/
Prognostic study
Language:
English
Journal:
Anatomy & Cell Biology
Year:
2011
Document type:
Article