Protective mechanisms of radix salviae miltiorrhizae against chronic alcoholic liver injury in mice / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 425-428, 2005.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-234857
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective mechanisms of Radix Salviae miltiorrhizae (RSM) on chronic alcoholic liver injury in mice.</p><p><b>METHODS</b>The chronic alcoholic liver injury mouse model was established. The morphologic change of hepatic tissue was observed with hematoxylin-eosin (HE) staining; the levels of toll-like receptor-4 (TLR-4) mRNA in hepatic tissue and hemeoxygenase-1 (HO-1) mRNA were determined using reverse transcription polymerase chain reaction (RT-PCR) technique; and the expression of TLR-4 protein was determined by immunohistochemistry method.</p><p><b>RESULTS</b>RSM could alleviate the fatty degeneration and adiponecrosis of hepatic cells induced by alcohol, down-regulate the expressions of TLR-4 mRNA and HO-1 mRNA, and significantly decrease the number of TLR-4 positive cells.</p><p><b>CONCLUSION</b>RSM could prevent liver injury from alcohol by way of influencing TLR-4 signal transcription.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Drugs, Chinese Herbal
/
Membrane Glycoproteins
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Receptors, Cell Surface
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Salvia miltiorrhiza
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Therapeutic Uses
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Drug Therapy
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Heme Oxygenase-1
/
Toll-Like Receptors
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2005
Document type:
Article