Identification of protein markers for gestational diabetes mellitus complicated by pregnancy-induced hypertensive syndrome / 南方医科大学学报
Journal of Southern Medical University
; (12): 1224-1227, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-235157
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To identify the serum protein markers for the gestational diabetes mellitus (GDM) complicated by pregnancy-induced hypertensive (PIH) syndrome to provide a molecular biological basis for the screening, prevention and therapy of the related diseases.</p><p><b>METHODS</b>Serum samples were collected from the patients with GDM, PIH syndrome, and GDM complicated by PIH syndrome. IgG and albumins were removed from the samples before SDS -PAGE. The protein bands showing significant differences among the 3 samples were collected, digested and identified with mass spectrometry, and the function of the identified proteins was analyzed.</p><p><b>RESULTS</b>Three SDS-PAGE were performed in parallel to confirm the differentially expressed proteins. Mass spectrometry indicated that the proteins showing obvious differences among the 3 samples were haptoglobin, protein SMG8 and apoptosis-inducing factor-1.</p><p><b>CONCLUSIONS</b>The protein markers identified in GDM complicated by PIH syndrome may be integrated into the proteomic database of gestational metabolic diseases. Identification of the associated protein markers may provide significant experimental data for the prevention, diagnosis and therapy of the related diseases.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Arterial Hypertension
/
Cardiovascular Disease
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Diabetes Mellitus
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Endocrine System Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Blood
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Haptoglobins
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Biomarkers
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Diabetes, Gestational
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Proteomics
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Hypertension, Pregnancy-Induced
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Diagnosis
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Electrophoresis, Polyacrylamide Gel
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Apoptosis Inducing Factor
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Methods
Type of study:
Diagnostic study
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Prognostic study
Limits:
Adult
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Female
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Humans
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Pregnancy
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Document type:
Article