Dimethoate induced oxidative damage and histopathological changes in lung of adult rats: modulatory effects of selenium and/or vitamin E / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 340-351, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-235549
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the efficiency of selenium and/or vitamin E to alleviate lung oxidative damage induced by dimethoate, an organophosphorus compound.</p><p><b>METHODS</b>Adult Wistar rats were exposed during 30 days either to dimethoate (0.2 g/L of drinking water), dimethoate+selenium (0.5 mg/kg of diet), dimethoate+vitamin E (100 mg/kg of diet), or dimethoate+selenium+vitamin E.</p><p><b>RESULTS</b>Exposure to dimethoate caused oxidative stress in lung evidenced by an increase of malondialdehyde, protein carbonyl groups and advanced oxidation protein products. An increase in glutathione peroxidase, superoxide dismutase, catalase and a decrease in acetylcholinesterase and butyrylcholinesterase activities, glutathione, non-protein thiols and vitamins C levels were observed. Histopathological changes in lung tissue were noted as emphysema, hemorrhages and hemosiderin deposits. Co-administration of selenium or vitamin E to the diet of dimethoate treated rats ameliorated the biochemical parameters as well as histological impairments. The joint effect of these elements was more powerful in antagonizing dimethoate-induced lung oxidative damage.</p><p><b>CONCLUSION</b>We concluded that selenium and vitamin E ameliorated the toxic effects of this pesticide in lung tissue suggesting their role as potential antioxidants.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Other Respiratory Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Acetylcholinesterase
/
Ascorbic Acid
/
Selenium
/
Vitamin E
/
Butyrylcholinesterase
/
Biomarkers
/
Lipid Peroxidation
/
Rats, Wistar
/
Oxidative Stress
Type of study:
Diagnostic study
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2012
Document type:
Article