The research progress of Aurora-B kinase and its inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 457-465, 2013.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-235643
Responsible library:
WPRO
ABSTRACT
Aurora-B as an important kinase to adjust the cell normal mitosis is a potent target for cancer treatment. Aurora-B is overexpressed in a broad range of tumor and tumor cells are more sensitive while Aurora-B is inhibited. Due to the key role of the Aurora-B in cell mitosis, the development of its inhibitors is becoming more and more important. Several small molecules inhibit with a similar efficacy both Aurora-A and Aurora-B, however, in most cases the effects resemble Aurora-B disruption by genetic methods, indicating that Aurora-B represents an effective therapeutic target. There were several Aurora-B kinase inhibitors which had entered the clinics and displayed good antitumor activity. In this review, we will outline the functions of Aurora kinase B in normal cell division and in malignancy. We will focus on recent preclinical and clinical studies that have explored the mechanism of action and clinical effect of Aurora-B inhibitors in cancer treatment.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
RNA, Messenger
/
Therapeutic Uses
/
Protein Kinase Inhibitors
/
Drug Therapy
/
Enzyme Activation
/
Aurora Kinase B
/
Genetics
/
Metabolism
/
Mitosis
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Document type:
Article