Glandular odontogenic cyst: report of two cases with cytokeratin 18 expression / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To report two cases of glandular odontogenic cyst and examine its cytokeratin 18,19 expression.</p><p><b>METHODS</b>Two cases of glandular odontogenic cyst were reported and studied. The cytokeratin 18, 19 expression in these two cases were also investigated using immuno-histochemical staining as well as in the situ hybridization of the cyst epithelium.</p><p><b>RESULTS</b>Histo-pathological examination revealed that ciliated columnar cells, squamous cells and low-columnar cells were found in the superficial layer of the lining epithelium. Several minor salivary glands, mainly composed of seromucous cells were observed near the satellite cyst. CK18 were expressed in all layers of the lining epithelium of varying intensity. CK18 was negative in lining epithelium of the daughter cyst, but CK19 was positive. CK18-mRNA was expressed in all the layers of the lining epithelium, the salivary glands and daughter cysts.</p><p><b>CONCLUSIONS</b>Histological features and CK18 expression may be indicative of the possibility of salivary glandular and odontogenic differentiation.</p>